The No. 4 Ohio State Buckeyes (5-1) take on a conference opponent when they visit the No. 5 Indiana Hoosiers (6-0) on Saturday, October 17, 2026 at Memorial Stadium (Bloomington, IN) in a Big Ten clash.

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Ohio St vs. Indiana Matchup Info

Game date: Saturday, October 17, 2026
Game time: 12 p.m. ET
Location: Bloomington, Indiana
Venue: Memorial Stadium (Bloomington, IN)
TV channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Ohio St vs. Indiana Odds and Prediction

Spread favorite: Buckeyes (-3.5)
Moneyline: Buckeyes (-177), Hoosiers (+145)
Total: 50.5 points
Pick ATS: Indiana (+3.5)
Pick OU: Over (50.5)
Prediction: Indiana 30, Ohio State 24

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Ohio St vs. Indiana Betting Records and Insights

Ohio State has covered four times in six chances against the spread this season.
Indiana has won just one game against the spread this year.
The Buckeyes have an ATS record of 3-2 when playing as at least 3.5-point favorites this season.
Ohio State games have gone over the point total four out of six times this season.
Indiana games have gone over the point total three out of six times this season.

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