Big Ten foes match up when the No. 4 Ohio State Buckeyes (5-1) and the No. 5 Indiana Hoosiers (6-0) square off on Saturday, October 17, 2026 at Memorial Stadium (Bloomington, IN).

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Ohio St vs. Indiana Matchup Info

Game date: Saturday, October 17, 2026
Game time: 12 p.m. ET
Location: Bloomington, Indiana
Venue: Memorial Stadium (Bloomington, IN)
TV channel: FOX
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Ohio St vs. Indiana Odds and Prediction

Spread favorite: Buckeyes (-3.5)
Moneyline: Buckeyes (-176), Hoosiers (+144)
Total: 50.5 points
Pick ATS: Indiana (+3.5)
Pick OU: Over (50.5)
Prediction: Indiana 30, Ohio State 24

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Ohio St vs. Indiana Betting Records and Insights

Ohio State has won four games against the spread this season, while failing to cover twice.
Indiana has won just one game against the spread this season.
When playing as at least 3.5-point favorites this season, the Buckeyes have an ATS record of 3-2.
In Ohio State's six games this season, the combined scoring has gone over the point total four times.
Indiana and its opponent have combined to hit the over three out of six times this season.

Mo Egger

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